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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
18.79
Human Site:
Y378
Identified Species:
31.79
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
Y378
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Chimpanzee
Pan troglodytes
XP_521839
646
71607
Y378
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
N333
L
G
L
K
Y
I
H
N
S
G
M
V
H
L
D
Dog
Lupus familis
XP_534051
887
95991
Y619
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
Y377
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Rat
Rattus norvegicus
Q63802
646
71478
C378
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
G337
K
D
L
L
L
Q
V
G
R
G
L
R
Y
I
H
Chicken
Gallus gallus
NP_001026352
641
70947
Y374
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Frog
Xenopus laevis
P47817
555
61670
L319
Q
E
L
K
E
I
L
L
Q
V
S
M
G
L
K
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
S365
N
R
R
M
H
F
L
S
E
L
E
L
K
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
N366
H
M
D
L
K
P
E
N
I
F
S
T
M
N
P
Honey Bee
Apis mellifera
XP_624069
589
66032
M354
G
L
R
Y
I
H
S
M
Q
L
V
H
M
D
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
K373
A
D
I
I
S
S
N
K
Q
N
N
H
R
M
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
K265
G
H
F
S
R
V
F
K
V
L
K
R
M
D
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
13.3
100
N.A.
100
6.6
N.A.
6.6
100
13.3
0
N.A.
20
0
N.A.
13.3
P-Site Similarity:
100
100
13.3
100
N.A.
100
20
N.A.
20
100
20
13.3
N.A.
33.3
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
36
% A
% Cys:
0
0
0
0
0
0
0
8
36
0
0
0
0
0
0
% C
% Asp:
0
15
8
0
0
0
0
0
0
0
0
0
0
22
15
% D
% Glu:
0
8
0
0
8
8
43
0
8
0
8
0
0
0
0
% E
% Phe:
0
0
8
0
0
8
8
0
0
8
0
0
0
0
0
% F
% Gly:
15
8
0
0
0
0
0
8
0
22
43
36
8
0
8
% G
% His:
43
8
0
0
8
8
8
0
0
0
0
15
8
0
8
% H
% Ile:
0
0
15
43
8
15
0
0
8
0
0
0
0
8
8
% I
% Lys:
8
0
0
15
8
0
0
15
0
0
8
0
8
0
8
% K
% Leu:
8
15
58
15
8
0
15
8
0
22
8
8
8
50
8
% L
% Met:
8
43
0
8
0
0
0
8
0
0
8
8
22
8
0
% M
% Asn:
8
0
0
0
8
36
8
15
8
43
8
0
0
8
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% P
% Gln:
8
0
0
8
36
8
0
0
22
0
0
0
0
0
0
% Q
% Arg:
0
8
15
0
8
0
0
0
8
0
0
15
8
0
0
% R
% Ser:
0
0
0
8
8
8
8
8
8
0
15
8
36
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% T
% Val:
0
0
0
0
0
8
8
0
8
8
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
8
36
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _